Closed haynescd closed 1 month ago
New Nodes Added
Use gene associations with variant to identify variants within gene
Queries the ChEMBL database for cytotoxicity assay data for a given list of drugs.
Queries the B3DB (Blood-Brain Barrier Database) for BBB permeability data and merges it with drug scores.
Produces a ranked list of drug candidates based on the combination of cytotoxicity, BBB and confidence z-scores.
Adding Use Case 32
New Nodes Added
GetGeneFromAssociations
Use gene associations with variant to identify variants within gene
Cytotoxicity CHEMBL API
Queries the ChEMBL database for cytotoxicity assay data for a given list of drugs.
BBB Permeability
Queries the B3DB (Blood-Brain Barrier Database) for BBB permeability data and merges it with drug scores.
Ranked List of Drugs
Produces a ranked list of drug candidates based on the combination of cytotoxicity, BBB and confidence z-scores.