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MaayanLab / enrichr_issues

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meaning of combined score #26

Closed rachellw closed 3 years ago

rachellw commented 3 years ago

Hi

I love your website it has given me so much insight into my data. Thanks for setting it up.

I was wondering, how is the combined score calculated please? I assume it is a combination of the odds ratio and p value and adjusted p value but can't find any details.

Is there a standard cutoff that people tend to use for combined value (equivalent to the 0.05 people use for p value?)

Thanks again for creating such a useful resource.

best wishes Rachel

AviMaayan commented 3 years ago

Hi @rachellw

The formula for the combined score is -ln(p-value)*odds-ratio. There is now guide for a good cut off but borderline p-values and very few overlapping genes (less than 3) should not be considered in most cases.

Best,

Avi

rachellw commented 3 years ago

HI Avi Thanks for your speedy and helpful answer best wishes Rachel

On Mon, Aug 9, 2021 at 2:50 PM AviMaayan @.***> wrote:

Hi @rachellw https://github.com/rachellw

The formula for the combined score is -ln(p-value)*odds-ratio. There is now guide for a good cut off but borderline p-values and very few overlapping genes (less than 3) should not be considered in most cases.

Best,

Avi

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rachellw commented 3 years ago

Thanks so much for your help - I later found the information on calculation of combined score on the website - it was a bit tricky to find as to reveal the description of combined score one has to hover the mouse over the heading of the P value column and to find the description of the p value one has to hover over the heading of the odds ratio column image