Another useful advantage of doing DE with single-cell data is that you can distinguish between DE due to genuine changes in the same set of cells, or DE due to changes in the population composition. So once DE genes are rigorously identified by summation, you can go back and look in more detail as to why they are changing.
LTLA
commented
8 years ago
Another useful advantage of doing DE with single-cell data is that you can distinguish between DE due to genuine changes in the same set of cells, or DE due to changes in the population composition. So once DE genes are rigorously identified by summation, you can go back and look in more detail as to why they are changing.