MarioniLab / miloR

R package implementation of Milo for testing for differential abundance in KNN graphs
https://bioconductor.org/packages/release/bioc/html/miloR.html
GNU General Public License v3.0
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Add NB-GLMM to master branch. #295

Closed MikeDMorgan closed 10 months ago

MikeDMorgan commented 10 months ago

This major update to Milo (2.0) introduces a mixed effect model. This can be used to model dependence between observations, including genetic relationships. Therefore, Milo can now be used to identify cell state quantitative trait loci (csQTL). More details are included in https://github.com/MorganResearchLab/Milo2.0Analysis_2023

codecov-commenter commented 10 months ago

Codecov Report

Merging #295 (47fb880) into master (3e4e264) will decrease coverage by 5.96%. The diff coverage is 50.94%.

:exclamation: Current head 47fb880 differs from pull request most recent head 1633c34. Consider uploading reports for the commit 1633c34 to get more accurate results

Impacted file tree graph

@@            Coverage Diff             @@
##           master     #295      +/-   ##
==========================================
- Coverage   61.65%   55.69%   -5.96%     
==========================================
  Files          19       30      +11     
  Lines        1476     3065    +1589     
==========================================
+ Hits          910     1707     +797     
- Misses        566     1358     +792     
Files Coverage Δ
R/buildGraph.R 61.81% <ø> (ø)
R/findNhoodGroupMarkers.R 68.42% <ø> (ø)
R/graphSpatialFDR.R 72.46% <ø> (+1.03%) :arrow_up:
R/makeNhoods.R 94.49% <100.00%> (ø)
R/plotNhoods.R 27.04% <ø> (ø)
R/milo.R 66.66% <0.00%> (ø)
R/annotateNhoods.R 91.30% <84.61%> (-3.70%) :arrow_down:
R/checkSeparation.R 91.66% <91.66%> (ø)
R/utils.R 87.27% <90.90%> (+2.42%) :arrow_up:
src/invertPseudoVar.cpp 74.07% <74.07%> (ø)
... and 10 more