Does the PAC design allow to use less control samples compared to PC design?
Plot AUPRC (or other metric) as a function of number of control donors for PC and PAC design (from 3 to 16 control donors). Take 3 random initialization for each number of samples, esp the lower numbers, to assess variance.
only 5 query samples (to always have more ctrl than query samples)
Select query samples that have most of the perturb_pop cells (otherwise high variability in cell numbers leads to high variance between different initializations)
Does the PAC design allow to use less control samples compared to PC design?
Plot AUPRC (or other metric) as a function of number of control donors for PC and PAC design (from 3 to 16 control donors). Take 3 random initialization for each number of samples, esp the lower numbers, to assess variance.