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MartinFXP / DawnRank

driver gene identification algorithm DawnRank 2014
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Normal Expression data #6

Open underbais opened 1 year ago

underbais commented 1 year ago

Hello

What is meant by Normal Expression data? In cancer research we RNAseq tumor only usually

Thanks

MartinFXP commented 1 year ago

Hi,

normal expression data is usually log transformed raw data. Raw data can be intensities from e.g., affymatrics or RNAseq count data. However, normalization can be more elaborate with software packges like edgeR (R package). As I wrote in #5 if you use the dawnrank differential expression function, the data needs to be logged, because differences are computed by substraction.