jafsia
commented
2 years ago Nice work
Closed chrilona closed 2 years ago
jafsia
commented
2 years ago Nice work
chrilona
commented
2 years ago Thank you sir.
On Tue, Nov 1, 2022, 6:41 PM JAFSIA Elisee @.***> wrote:
Merged #53 https://github.com/Mboalab/Outreachy_December_2022-March_2023-Internships-Typhoid-diagnostics-Project/pull/53 into main.
— Reply to this email directly, view it on GitHub https://github.com/Mboalab/Outreachy_December_2022-March_2023-Internships-Typhoid-diagnostics-Project/pull/53#event-7714599634, or unsubscribe https://github.com/notifications/unsubscribe-auth/AXW4EUWA3SG2ATDEK6WKXKLWGE2ZFANCNFSM6AAAAAART7J7W4 . You are receiving this because you authored the thread.Message ID: <Mboalab/Outreachy_December_2022-March_2023-Internships-Typhoid-diagnostics-Project/pull/53/issue_event/7714599634 @github.com>
MBOA LAB 2022-2023 TYPHOID DIAGNOSTIC PROJECT OVERVIEW
Mboalab is an open and collaborative space located in the village of Mefou-Assi, Yaounde, Cameroon. The aim of Mboalab is to catalyze sustainable development and improve people's living conditions through open science. We bring together researchers, scholars, educationists, policy makers and the general public to discuss, conceive and implement projects responding to the health, economic and social needs of the community. Our approach focuses on the integration of local knowledge by centering the local community especially women.
In an effort to improve the diagnosis and treatment of Typhoid disease.Mboa lab aims to develop
PROJECT AIM Improve diagnostics of typhoid through Open Science: An Artificial Intelligence-based technique
CAUSES OF TYPHOID AND EFFECTS ON AN INDIVIDUAL AND THE PUBLIC Typhoid fever is caused by Salmonella typhi bacteria . The bacteria thrives in contaminated water and food, feces of human carriers of the bacteria .The disease is rare in developed countries and a common condition in third world countries.
It is still a serious health threat in the developing world, especially for children. After the ingestion of contaminated food or water, the Salmonella bacteria invade the small intestine and enter the bloodstream temporarily.
The bacteria are carried by white blood cells in the liver, spleen, and bone marrow, where they multiply and re-enter the bloodstream. Persons affected develop symptoms, including fever, at this point. Bacteria invade the gallbladder, biliary system, and the lymphatic tissue of the bowel. Here, they multiply in high numbers. The bacteria pass into the intestinal tract and can be identified in stool samples.
SYMPTOMS AND SIGNS Intestinal bleeding or holes in the intestine are the most serious complications of typhoid fever. They usually develop in the third week of illness. In this condition, the small intestine or large bowel develops a hole. Contents from the intestine leak into the stomach and can cause severe stomach pain, nausea, vomiting and bloodstream infection (sepsis). This life-threatening complication requires immediate medical care. Other Symptoms include: Weakness Stomach pain Headache Diarrhea or constipation Cough Loss of appetite The danger from typhoid fever or paratyphoid fever doesn’t end when symptoms disappear.
DIAGNOSIS The bacteria is not always detected the first time so a series of tests may be normally conducted.
A diagnosis of typhoid fever can usually be confirmed by analyzing samples of blood, stool, or urine cultures. Testing a sample of bone marrow is a more accurate way of diagnosing typhoid fever.Getting the sample is both time-consuming and painful, normally done when other tests are inconclusive. Stool cultures are sensitive in the early and late stages of the disease, but it may be necessary to perform blood cultures to make a definitive diagnosis.
In extreme cases marrow cultures are carried out not by the duration of disease but by the extent of antibacterial therapy before presentation. Bacteriological recovery is faster from marrow cultures.
TREATMENT Most people who have typhoid fever feel better a few days upon antibiotic treatment, a small number however succumbs to complications.
There are however vaccines against typhoid fever that are partially effective and are usually reserved for those who may be exposed to the disease or who are traveling to areas where typhoid fever is common.
As a precaution, young children who develop typhoid fever may be admitted to hospital. In hospital, you'll have antibiotic injections and you may also be given fluids and nutrients directly into a vein through an intravenous drip.
Surgery may be needed if you develop life-threatening complications of typhoid fever, such as internal bleeding or a section of your digestive system splitting which is very rare in people being treated with antibiotics.
Most people respond well to hospital treatment and improve within 3 to 5 days, but it may be several weeks until you're well enough to leave the hospital.
ROLES AND RESPONSIBILITIES
The term “Mboa” means to unify, the project aims to empower the community and empower the population with tools and skills that improve the living standards in the community.
The project acts as a mediation between the local community and scholars to meet direct and immediate needs and help in addressing neglected tropical diseases such as typhoid.
Through the integrating open science, Mboalab jointly also trains the young generation and gives them practical interaction with molecular Biology.
SCOPE AND CONSTRAINTS Widespread antibiotic availability and self-prescriptions is another reason for the low sensitivity of blood cultures. Although bone marrow cultures are more sensitive, they are difficult to obtain, relatively invasive, and of little use in public health settings. The use of bacteriological cultures for the diagnosis of typhoid infection is cost-intensive and technically difficult, hence the need for other diagnostic tests.
EXPECTED OUTCOMES AND RESULTS The aim of Mboalab is to catalyze sustainable local development and improve people’s living conditions through open science.
To this end, the main missions of Mboalab are as follows:
Provide community and lifelong education for the population, as well as formal education for the younger generations. Serve as a platform for exchanges on issues related to local context; mediate between local communities and academia. Propose solutions that meet the needs of communities, using local knowledge and open digital technologies. Raise public awareness of environmental issues and prevention of diseases as typhoid. Facilitate access to basic health care through innovative health tech solutions.