Merck / BioPhi

BioPhi is an open-source antibody design platform. It features methods for automated antibody humanization (Sapiens), humanness evaluation (OASis) and an interface for computer-assisted antibody sequence design.
https://biophi.dichlab.org/
MIT License
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Vernier CDR Grafting #26

Closed salvatta2 closed 1 year ago

salvatta2 commented 1 year ago

Hi, I see that the CDR grafting option in the server performs straight grafting. Is there any way to automatically perform "Vernier" CDR grafting while retaining key "back-mutations" in the Vernier zones (as you describe in the paper)? Thank you!! SG

prihoda commented 1 year ago

Hi @salvatta2 sorry for the late reply. You can use "Kabat + Vernier" CDR definition in the settings, this will avoid any mutations in those regions.

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salvatta2 commented 1 year ago

Hi David, many thanks for your reply, sorry my fault I didn't see this on the web server. Now clear! Kind regards, Salva

On Sat, 15 Oct 2022 at 13:58, David Příhoda @.***> wrote:

Hi @salvatta2 https://github.com/salvatta2 sorry for the late reply. You can use "Kabat + Vernier" CDR definition in the settings, this will avoid any mutations in those regions.

[image: image] https://user-images.githubusercontent.com/2894124/195985191-d87c6895-1312-472c-96e9-0d6e42d418e5.png

— Reply to this email directly, view it on GitHub https://github.com/Merck/BioPhi/issues/26#issuecomment-1279730427, or unsubscribe https://github.com/notifications/unsubscribe-auth/A3MJICUTR5J5UFA2NLXPUZLWDKMAHANCNFSM6AAAAAAQ22X26Q . You are receiving this because you were mentioned.Message ID: @.***>