Merck / simtrial

Clinical trial simulation for time-to-event endpoints
https://merck.github.io/simtrial/
GNU General Public License v3.0
18 stars 8 forks source link

Change the milestone test statistics to the log-log transformation #210

Closed LittleBeannie closed 8 months ago

LittleBeannie commented 8 months ago

As indicated by Klein, J. P., Logan, B., Harhoff, M., & Andersen, P. K. (2007). Analyzing survival curves at a fixed point in time. Statistics in Medicine, 26(24), 4505-4519, the log-log transformation is more robust. So we will switch from the native approach (surv diff / std) to the log-log transformation.