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MissionBio / mosaic

Tertiary analysis package to visualize single-cell data generated by the Tapestri Platform.
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group_by_genotype() v2.0.7 vs v3.0.1 #17

Open FedericaBrando opened 1 year ago

FedericaBrando commented 1 year ago

Hi, I had done some analysis with the tool last year and I used the group_by_genotype() function in Mosaic version 2.0.7. Lately I came across the same data and I wanted to perform some more analysis and I updated the tool to version 3.0.1 and, interestingly enough, I got some different results than the one I had a year before.

I was wondering if anything has changed in the underlying algorithm that could explain these changes.

I am using the same .h5 file for both analysis.

Thank you

KKJSP commented 1 year ago

@FedericaBrando, the group_by_genotype algorithm has not changed. However, fitler_variants has been modified in v3.0.1. If you were using the NGT_FILTERED layer in group_by_genotype then you can expect to see slightly different results.

Here is the changelog for v3