This is a placeholder to remind us to discuss how we'd want to update and curate any reaction direction and thermodynamic reversibility in the biochemistry and in the templates. We came across a good example:
In all the pathways I've observed, the reaction is the last step in proline biosynthesis, but the deltaG and thermodynamic heuristics list it as irreversible going from left to right. It needs to be at least reversible for proline biosynthesis to occur, at least in eukaryotes.
This is a placeholder to remind us to discuss how we'd want to update and curate any reaction direction and thermodynamic reversibility in the biochemistry and in the templates. We came across a good example:
rxn00929 (1) NAD[0] + (1) L-Proline[0] > (1) NADH[0] + (2) H+[0] + (1) 1-Pyrroline-5-carboxylate[0]In all the pathways I've observed, the reaction is the last step in proline biosynthesis, but the deltaG and thermodynamic heuristics list it as irreversible going from left to right. It needs to be at least reversible for proline biosynthesis to occur, at least in eukaryotes.