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MyDigiTwinNL / CDF2Medmij-Mapping-tool

Tool for transforming Cohort-study Data (CDF) into FHIR/MedMij compliant resource bundles
Apache License 2.0
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CKD-EPI Equation version #9

Closed hcadavid closed 5 months ago

hcadavid commented 10 months ago

@baukearends the CKD-EPI Equations for Glomerular Filtration Rate (GFR) was implemented according to the specification:

https://github.com/MyDigiTwinNL/CDF2Medmij-Mapping-tool/blob/36a3eaa217770d9463737e3feda6fe50fc0e0570/src/lifelines/eGFR.ts#L125-L163

and a number of test cases were included using the values given by this calculator as a reference: https://www.mdcalc.com/calc/3939/ckd-epi-equations-glomerular-filtration-rate-gfr :

https://github.com/MyDigiTwinNL/CDF2Medmij-Mapping-tool/blob/36a3eaa217770d9463737e3feda6fe50fc0e0570/src/__tests__/egfr.test.ts#L14-L30

However, while doing so I found the following:

The 2021 CKD-EPI equation is now the recommended standard. This version does not include race, as do the 2009 and 2012 CKD-EPI creatinine and creatinine-cystatin C equations.

Do you think we should consider using this version of the equation instead?

baukearends commented 10 months ago

Hi Hector,

This is precisely the point I raised on the Slack channel as well. According to this article, in Europe the 2009 formula is most often used, without the race coefficient. This is a more accurate estimate of GFR than the new formula.

hcadavid commented 5 months ago

Thanks @baukearends for clarifying this. Something important to be considered then is ensuring that any eGFRs value given as an input (for an eventual prediction model) was calculated with this specific formula.