but essentially we need a gene set where there is co-lethality of our primary genes (some may have alternate primary symbols):
FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCD2, FANCI, UBE2T
FANCD1 (BRCA2), FANCJ, FANCN, FANCO, FANCP, FANCQ, FANCR, FANCS, FANCV, FANCU
FAAP100, FAAP24, FAAP20, FAAP16 (MHF1), FAAP10 (MHF2)
These will be from iRNA screens, DT-40 cells, and perhaps newer CRISPR pubs.
There are also other types of lethality from literature using DT-40 cells and synthetic lethal screens.
@kshefchek perhaps we have enough data already in the system from the MODs? or @lwinfree can help identify sources
We need to pull a series of data to inform which genes to look for variants in.
There is a google doc here for reference.
This relates to Set-6.
but essentially we need a gene set where there is co-lethality of our primary genes (some may have alternate primary symbols): FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCD2, FANCI, UBE2T FANCD1 (BRCA2), FANCJ, FANCN, FANCO, FANCP, FANCQ, FANCR, FANCS, FANCV, FANCU FAAP100, FAAP24, FAAP20, FAAP16 (MHF1), FAAP10 (MHF2)
These will be from iRNA screens, DT-40 cells, and perhaps newer CRISPR pubs. There are also other types of lethality from literature using DT-40 cells and synthetic lethal screens.
@kshefchek perhaps we have enough data already in the system from the MODs? or @lwinfree can help identify sources
@dnahotline will advise as needed