Known drugs not found (and other issues) for What treats Hookworm Infectious Disease

[khanspers]

Query 1: What drugs may treat Hookworm Infectious Disease? (MONDO:0005799)

CI: https://ui.ci.transltr.io/results?l=Hookworm%20Infectious%20Disease&i=MONDO:0005799&t=0&q=95b9cf5c-f99a-43bc-9ecb-168ad0681677 Results: None

Test: https://ui.test.transltr.io/results?l=Hookworm%20Infectious%20Disease&i=MONDO:0005799&t=0&q=4e75ab7f-f5de-4d0f-b137-8f7d1b0a7130 Results: 500. Known treatments albendazole and mebendazole are NOT found.

UI: https://ui.transltr.io/results?l=Hookworm%20Infectious%20Disease&i=MONDO:0005799&t=0&q=3c676b42-ddd5-4838-8061-363c9902941f Results: 500 Problems:

• Searching for albendazole or mebendazole gives multiple results, but none of them are direct "x-treats-y" interactions but rather 2-hop results for something else, see below for example.

• Many of the top-scoring results are for the more general term "infectious disease", for example:

Query 2: What drugs may treat Ancylostomiasis? (MONDO:0005645)

When typing in "hookworm disease" the autocomplete shows "Ancylostomiasis (matched on Hookworm infectious disease)" so I decided to try that instead. (Ancylostomiasis is disease from a subset of hookworms, Ancylostoma)

CI: https://ui.ci.transltr.io/results?l=Ancylostomiasis&i=MONDO:0005645&t=0&q=a814bf56-0d3e-431a-bf4f-3b2e2d4e7d18 Results: 519.

• Albendazole is found, but with a not-great score of ~85, after things like Air, Date allergenic extract etc
• Mebendazole is found with a very low score of 25

Test: https://ui.test.transltr.io/results?l=Ancylostomiasis&i=MONDO:0005645&t=0&q=0fe7a2ea-bc4d-49ef-9f75-0727b6fe6b8b Results: 512

• Albendazole is the top result!
• Mebendazole also found

UI: https://ui.transltr.io/results?l=Ancylostomiasis&i=MONDO:0005645&t=0&q=7e80ae67-46c2-4f87-ab46-0cdaa899fb89 Results: 8

• Mebendazole and Albendazole both found.

[khanspers]

Ran the query 1 (What drugs may treat Hookworm Infectious Disease?) on ui.transltr.io and got 4 answers: Mebendazole, Pyranthel, Thiabendazole and Dichlorophen. The first 3 are correct but the last one, Dichlorophen, is a veterinary drug not used in people. Coming from infores:drug-repurposing-hub via kp-molecular.

Still missing from results: Albendazole (one of the two main treatments for hookworm)

[sierra-moxon]

from TAQA: using the "test asset" label to mark that this ticket has been converted into a series of P/F tests in the information radiator.

[sierra-moxon]

from TAQA: we need to identify the test asset id that this is formalized in and then see which ARAs need to do work and assign out. (sierra will track down)

[khanspers]

Latest test in test gives the same 4 results: https://ui.test.transltr.io/main/results?l=Hookworm%20Infectious%20Disease&i=MONDO:0005799&t=0&r=0&q=fabee1a2-2569-4f4c-bf44-6792dec7c336

Still no Albendazole.