Pregnenolone succinate - Can't find evidence it's Indicated for Disease

[sstemann]

the link out says: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2105373/

https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Pregnenolone+succinate

https://ui.test.transltr.io/main/results?l=Autism&i=MONDO:0005260&t=0&q=9c1a9505-b5c7-4f1c-981e-a2a48358a803

tagging @newgene and @brettasmi - I'm not sure if this is coming from Improving or from the annotator.

[gglusman]

See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194260/

[sstemann]

is this where the UI is getting the "indicated for" tag from?

[gglusman]

It seems to be getting it via Chembl from Clinical Trials: https://clinicaltrials.gov/search?id=%22NCT01881737%22OR%22NCT02627508%22 The paper I linked is the one reporting the results of the completed trial.

[sstemann]

thanks for the paper, i'm still hoping to understand where the indicated for disease tag is coming from. It's been raised by our FDA and pharma alumni.

[newgene]

I know annotator does provide this max_phase info from Chembl, will need UI team to confirm if annotator is the source for rendering this table column.

[sstemann]

@gprice1129 it looks like, the Chembl max_phase in this example is "2" "clinical candidate drug". i don't think that's the same as indicated for. can you confirm?

[gprice1129]

We get the "indicated for" tag directly from the annotator by way of the chembl.indications attribute. @newgene @sstemann

[brettasmi]

imProving returns the max_phase attribute for indication edges from CHEMBL.

[newgene]

@sstemann the indications data from the annotator for this particular drug is returned as this:

https://biothings.ncats.io/annotator/CHEMBL.COMPOUND:CHEMBL2105373?fields=chembl

[cbizon]

The attribute should only be applied in the UI if the annotation is in chembl indications AND the Phase = 4. Per @vdancik at Jan Relay

[sstemann]

@gprice1129 it looks like the max_phase_for_ind https://biothings.ncats.io/annotator/CHEMBL.COMPOUND:CHEMBL2105373?fields=chembl is 4. Can you please update the UI to apply indicated for as Vlado recommended at the relay?

https://ui.test.transltr.io/main/results?l=Autism&i=MONDO:0005260&t=0&r=0&q=5236e220-4e90-46f2-a1fb-85d0c2aa14f1

[gprice1129]

@sstemann this is an issue we are planning to fix this cycle.

[sstemann]

@gprice1129 I believe this is still an issue, in Test

https://ui.test.transltr.io/main/results?l=Autism&i=MONDO:0005260&t=0&r=0&q=67bd84e7-57bf-448e-b6bf-9afa1315c72a

https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL708/

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f78b278-a0b3-47ce-bbad-5dad7012896a

there are 38 drugs in the Drugs Indicated for Autism filter and i just don't think that's correct

[sstemann]

This continues to be an issue - for Autism in the Test UI on 4/29 - Oxytocin is Drug Indicated for - but according to its label, DrugBank its indicated for antepartum to initiate or improve uterine contractions.

https://ui.test.transltr.io/main/results?l=Autism&i=MONDO:0005260&t=0&r=0&q=d5c4dc4e-a143-404f-b61e-48f3c6ca436e

The CTs that are linked - inidicate Phase 2for the Oxytocin - Autism https://clinicaltrials.gov/study/NCT01308749

[gglusman]

Checked our upcoming KPs:

FDA approvals: indeed none of the 38 labels for oxytocin indicate it for ASD. Clinical Trials: there is a clinical trial at phase 4 for Syntocinon (Oxytocin) for Autism Spectrum Disorders.

[sstemann]

this is nice also: