search

NCATSTranslator / Feedback

A repo for tracking gaps in Translator data and finding ways to fill them.
7 stars 0 forks source link

What drugs may treat Klinefelter Syndrome - top results includes Benzo(a)pyrene #677

Closed khanspers closed 9 months ago

khanspers commented 10 months ago

Query: What drugs may treat Klinefelter Syndrome? (MONDO_0006823) Results: https://ui.transltr.io/main/results?l=Klinefelter%20Syndrome&i=MONDO:0006823&t=0&r=0b10660a&q=fbb2bb98-94ad-407e-90ec-9d48512e3b65

The second result returned is Benzo[a]pyrene, a polycyclic aromatic hydrocarbon that is a carcinogen as well as toxic to many organ systems etc.

The paths look like this: Screen Shot 2024-01-05 at 4 48 19 PM

Treats edge is coming from UnSecret Agent with no knowledge source / evidence. The other paths are technically correct given the evidence, but maybe Benzo[a]pyrene should be on a block list? (Do we have such a list for compounds?) It doesn't look so good to have this obviously incorrect result as the second result.

khanspers commented 10 months ago

Update: the same query on test does NOT include Benzo(a)pyrene as a result, so maybe this ticket can be closed.

https://ui.test.transltr.io/main/results?l=Klinefelter%20Syndrome&i=MONDO:0006823&t=0&r=426f052c&q=6231f720-794b-45c6-b818-9c7b56420622

sierra-moxon commented 10 months ago

tested again at TAQA - can not reproduce on TEST with a new query, closing (noting "water" treats it, we're looking into that in another ticket).

@sharatisrani will file a sub-issue to put this chemical in the block list completely.

sharatisrani commented 10 months ago

Benzo(a)pyene DOES need to belong on blocked list. It is reported as a carcinogen, even ChatGPT catches that.

sierra-moxon commented 9 months ago

@khanspers - thanks for this ticket!! I moved the carcinogen issue to the block list repo here: https://github.com/NCATSTranslator/Blocklists/issues/22 if you want to follow.