Tobacco smoke pollution treats Alzheimer's?

NCATSTranslator / Feedback

A repo for tracking gaps in Translator data and finding ways to fill them.

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Tobacco smoke pollution treats Alzheimer's? #687

Open gglusman opened 10 months ago

gglusman commented 10 months ago

https://ui.test.transltr.io/main/results?l=Alzheimer+Disease&i=MONDO%3A0004975&t=0&r=ed9a439c&q=90ef5948-3fed-4641-ba99-6a566cec01aa

Direct path shows Unsecret as Knowledge Source. Two-hop path offers pollution as a treatment for AD since the pollution affects a gene that is associated with the disease. Both edges are at face value very weak, so it's surprising for their combination to score 4.54/5.00, lacking information about directionality.

There's literature support for tobacco smoke pollution activating ATF3, and ATF3 activation mediating AD.

sierra-moxon commented 10 months ago

from TAQA: for MVP1 - "tobacco smoke should never be a treatment" -- Tyler. @webyrd - is it possible that this can be blocked on an ARA basis, or is this feasible albeit a bit odd?

gglusman commented 10 months ago

Perhaps I should have been more explicit about it, but to me the main issue here is the reasoning. A affects B associated_with C hardly equates to A treats C. Even A may_treat C is unwarranted, since the evidence for that isn't any stronger than the evidence for the opposite direction (e.g., A causes C, or A exacerbates C).

kaiwenho commented 7 months ago

"tobacco smoke pollution" has been added to the result blocked list of Unsecret. This answer has been removed from the CI, TEST, and PROD environments. A view in UI PROD: https://ui.transltr.io/main/results?l=Alzheimer%20Disease&i=MONDO:0004975&t=0&r=0&q=8034d934-4f0c-4f33-9cc4-004bb3869788