Which KP provides information relating ChemicalEntities to BiologicalProcess?

[karafecho]

The QotM identified a data gap related to ChemicalEntity – BiologicalProcess relationships. For example, a SME requested this information to identify mechanistic explanations for the observation that cannabidiol is generally safe except in patients taking valproic acid.

[sierra-moxon]

@sandrine-m @vdancik - is this something MolePro already provides? Is it possible that the data sources that provide this general kind of information are missing information for cannabidiol?

[sierra-moxon]

From TAQA: Vlado: we have some chemical->pathway (not the entire biological process)

[capasfield]

Vlado says YES. Vlado and Sandrine to update and then off to Kara.

[sandrine-m]

Confirmed: In MolePro we have connections between compounds and biological processes from BiGG models and CTD.

[sierra-moxon]

Hi @karafecho - can this be closed? :)

[karafecho]

@sandrine-m : Perhaps you can post an example query?

[vdancik]

{
    "message": {
        "query_graph": {
            "nodes": {
                "n2": {
                    "ids":["PUBCHEM.COMPOUND:10032468"]
                },
                "n3": {
                    "categories": [
                        "biolink:BiologicalProcess"
                    ]
                }
            },
            "edges": {
                "e03": {
                    "subject": "n2",
                    "object": "n3",
                    "predicates": [
                        "biolink:related_to"
                    ]
                }
            }
        }
    }
}

[karafecho]

Thank you, Vlado. This issue can now be closed.