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NCATSTranslator / Feedback

A repo for tracking gaps in Translator data and finding ways to fill them.
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Support Graph includes a rare disease as being treated by 390+ Drugs #733

Closed sstemann closed 6 months ago

sstemann commented 8 months ago

If you run What may downregulate GNAS (human) in Test you should get these results: https://ui.test.transltr.io/main/results?l=GNAS%20(Human)&i=NCBIGene:2778&t=2&r=0&q=ba0ffb85-71af-47c0-a4d5-c965cbbe9061

If you filter the above results by Node Type = Disease, there are 397 results with a disease in its inferred path

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When you expand these results with the Disease Node - they appear to all be result [Result] treats Mccune-albright Syndrome caused by GNAS

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Maybe all of these results treat symptoms of MAS and so this is useful information. So looking for feedback. These seem to come from OpenPredict via ARAGORN

CaseyTa commented 6 months ago

OpenPredict was previously returning all drugs regardless of prediction score, so many drugs were being returned with low scores. We've changed OpenPredict's default behavior to only return results with score > 0.5, which yields 3 results for MAS. These changes are deployed in CI and should be in Test soon.

CaseyTa commented 6 months ago

Retested this in Test and no longer seeing the above behavior.

https://ui.test.transltr.io/main/results?l=GNAS%20(Human)&i=NCBIGene:2778&t=2&r=0&q=0d5bf250-1182-4be7-a02f-010e908a1216