X - decreases Y - decreases Z != X decreases Z

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X - decreases Y - decreases Z != X decreases Z #762

Open TranslatorIssueCreator opened 5 months ago

TranslatorIssueCreator commented 5 months ago

Type: Bug Report

URL: https://ui.test.transltr.io/main/results?l=Lepirudin&i=PUBCHEM.COMPOUND:118856773&t=4&r=0&q=9c30d7a5-be5f-4f44-a12e-376369954f57

ARS PK: 0951aef6-f1a0-4061-9a45-66a6d94767ef

Steps to reproduce:

What genes may be downregulated by:Lepirudin as 1 example search for TNFRSF1A

Screenshots:

sandrine-muller-research commented 5 months ago

A lot of top answers show the same similar reasoning chain that is not answering the question asked: GENE X (output/answer) upregulates GENE Y (intermediate node) Has decreased activity or abundance of Lepirudin. As an example, for TNFRSF1A:

see complete list in test asset sheet. To note that I did not put TNFRSF1A as a never_show because there is other (weak though) evidence of another correct reasoning path.

sandrine-muller-research commented 5 months ago

Perhaps related to issue #755 but the involved ARA here is BTE.

sandrine-muller-research commented 5 months ago

This type of reasoning overloads the top results : this could be an issue for O&O as well.