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NCATSTranslator / Feedback

A repo for tracking gaps in Translator data and finding ways to fill them.
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Inferred path with (extra?) "drug x - Same as - chemical x" hop #951

Closed khanspers closed 2 weeks ago

khanspers commented 1 month ago

In the results from the query "What drugs may treat conditions related to Leukemia", one of the drugs returned is Anistreplase with several inferred paths. The first hop in one of the paths is "Anistreplase (drug) - Same as - Anistreplase (chemical)". I haven't seen this before, so I'm wondering if it's a bug that this is shown in the UI?

Drug: (https://go.drugbank.com/drugs/DB00029) Chemical: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108250/

Screen Shot 2024-09-19 at 9 39 22 AM

It's coming from ARAX/DrugBank.

https://ui.test.transltr.io/results?l=Leukemia&i=MONDO:0005059&t=0&r=0&q=012e64bb-8aa6-43b9-bc8c-a8f17d0ecbb3

Will update this ticket if I find other examples.

sstemann commented 1 month ago

looks like it's coming from ARAX, i'm not sure who to assign it to so asking @edeutsch to take a look

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edeutsch commented 1 month ago

The current RTX-KG2 has some Drug - same_as - Chemical edges. Is that specifically disallowed?

In any case, the next RTX-KG2 in dev and CI no longer has these, so this will disappear in coming releases to TEST and PROD.

khanspers commented 2 weeks ago

Anistreplase is no longer returned as a result in test. Closing.