NCATSTranslator / Ordering-Organizing

ARS Level O&O
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ARAs returning non-target disease results (ARAX, ROBOKOP) #34

Closed sharatisrani closed 1 year ago

sharatisrani commented 1 year ago

"What drug treats Ehlers-Danlos" gives [high-scored] results for all sorts of other diseases, pivoted on drug. Especially versatile drugs.

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This appears to be happening with ARAX and ROBOKOP (maybe ARAGORN)

Is this ok? Here is the list of diseases that were returned to that question:

MONDO:0001071 - Hypertrophic cardiomyopathy MONDO:0002025 - Breast cancer MONDO:0002081 - Hypertension MONDO:0002254 - Alzheimer's disease MONDO:0003847 - Asthma MONDO:0003900 - Autism spectrum disorder MONDO:0004335 - Cystic fibrosis MONDO:0004995 - Diabetes mellitus type 2 MONDO:0005066 - Epilepsy MONDO:0005093 - Gaucher disease MONDO:0005240 - Hemophilia MONDO:0005267 - Huntington's disease MONDO:0005307 - Inflammatory bowel disease MONDO:0005328 - Leukemia MONDO:0005336 - Liver cirrhosis MONDO:0005381 - Lymphoma MONDO:0005385 - Major depressive disorder MONDO:0005560 - Multiple sclerosis MONDO:0006999 - Parkinson's disease MONDO:0007523 - Rheumatoid arthritis MONDO:0007526 - Schizophrenia MONDO:0011142 - Systemic lupus erythematosus MONDO:0015286 - Thrombophilia MONDO:0016002 - Von Willebrand disease MONDO:0017314 - Myocardial infarction MONDO:0019052 - Prostate cancer MONDO:0019567 - Endometriosis MONDO:0020066 - Chronic obstructive pulmonary disease (COPD) MONDO:0020121 - Osteoporosis

sharatisrani commented 1 year ago

ARAX clarified that with _with knowledgetype "inferred", it behaves as expected. But here is a PK where ROBOKOP returns all sort of other diseases when Q'd for Ehlers-Danfos: c8c2369b-a722-4985-ad42-f0be4f8a8d6d?

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But pls hold off pending a discussion with @dkoslicki

sharatisrani commented 1 year ago

This issue can be tied to #422 and #445 identified by @suihuang-ISB in his report on "Embarrassing Results"

sharatisrani commented 1 year ago

Issue not observed for a couple of weeks, as the 5 ARAs got finalized and all other agents not factored directly into ARS removed from the scoring. Can reopen issue if needed.