SmallMolecule <treats, disrupts, prevents, affects> PhenotypicFeature (HP:0011015 Abnormal blood glucose concentration))

sstemann commented 2 years ago

Query: Blood_Glucose_Concen.json PK: 2ac4824e-a783-4633-85a7-f4188020d240

colleenXu commented 2 years ago

This looks like a "Disease vs PhenotypicFeature" thing. Also an HP -> UMLS issue.

If one uses a "Disease" hyperglycemia ID (MONDO:0002909), one gets back results from every ARA (I didn't wait for Aragorn to finish loading when I took the screenshot, but I assume it has a large response). This MONDO ID is mapped by Node Normalizer to UMLS:C0020456 which has assertions in semmeddb.

https://arax.ncats.io/?r=f32fa057-2085-4896-bc75-fa8e1cec0188

Screen Shot 2022-05-23 at 7 45 30 PM

In comparison, the HP ID used in the original query is mapped by Node Normalizer to UMLS:C4023597, which doesn't seem to have any assertions in semmeddb.

disease query

``` { "message": { "query_graph": { "edges": { "e00": { "subject": "n01", "object": "n00", "predicates": [ "biolink:treats", "biolink:disrupts", "biolink:prevents", "biolink:affects" ] } }, "nodes": { "n00": { "ids": [ "MONDO:0002909" ], "categories": [ "biolink:Disease" ] }, "n01": { "categories": [ "biolink:SmallMolecule" ] } } } } } ```

sstemann commented 8 months ago

https://ui.ci.transltr.io/main/results?l=Abnormal%20Blood%20Glucose%20Concentration&i=HP:0011015&t=0&q=313574d3-8d3b-446c-97e2-132d1b918bfb

NCATSTranslator / testing

SmallMolecule <treats, disrupts, prevents, affects> PhenotypicFeature (HP:0011015 Abnormal blood glucose concentration)) #203