NCI-Thesaurus / thesaurus-obo-edition

OBO Library edition of NCIt
22 stars 8 forks source link

definition for retinal cell neoplasm #28

Open cmungall opened 6 years ago

cmungall commented 6 years ago

This class lacks a text definition:

NCIT:C7061 ! Retinal Cell Neoplasm

The term 'retinal cell' can be a bit ambiguous. Broadly, it could be any cell located in the retina, including cells of the retinal vasculature, or pigmented epithelial cells. But I think the intent is to exclude these (otherwise this would be equivalent to NCIT:C4800 "Retinal Neoplasm").

In MONDO we have been axiomatizing with

CL:0009004 ! retinal cell

Which is equally broad a name, but is restricted to "neural cell" and part-of some "retina".

This seems consistent with the OWL definition in NCIT:

Neoplasm by Morphology and Retinal Neoplasm and (Disease_Has_Primary_Anatomic_Site some Retina) and (Disease_Has_Normal_Tissue_Origin some Neural Retina) and (Disease_Has_Normal_Cell_Origin some Photoreceptor Cell) and (Disease_Has_Abnormal_Cell some Neoplastic Retinal Cell)

On reflection in CL we should probably call this a neural retina cell..

Based on the OWL definition in NCIT, I suggest a text def "A neoplasm that arises from the neural cells of the neural layer of the retina"

cmungall commented 6 years ago

and also add synonyms as appropriate