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NCI-Thesaurus / thesaurus-obo-edition

OBO Library edition of NCIt
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NTR: Braf Kinase Inhibitor #37

Open ukemi opened 6 years ago

ukemi commented 6 years ago

term name: Braf Kinase Inhibitor is_a: Raf Kinase Inhibitor definition: Any substance that inhibits Braf Kinase, an enzyme active in signal transduction in the Ras pathway. definition reference: PMID:29628797 exact synonym: B-Raf kinase inhibitor exact synonym: Braf Inhibitor exact synonym: B-raf Inhibitor

Is there any plan to axiomatize these? Seems like really good candidates for DOS-DPs.

Should be children of this class?: B-Raf/VEGFR-2 Inhibitor RAF265 (How are inhibitors that inhibit more than one activity classified?) pan-RAF Inhibitor LXH254 Pan-RAF Inhibitor LY3009120 pan-RAF Kinase Inhibitor CCT3833 pan-RAF Kinase Inhibitor TAK-580 Raf Kinase Inhibitor HM95573 (assuming that mutant Braf such as V600E are included in this class) RAF Kinase Inhibitor XL281 BRAF Inhibitor ARQ 736 BRAF Inhibitor PLX8394 BRAF(V600E) Inhibitor CEP-32496 BRAF(V600E) Kinase Inhibitor RO5212054 BRAF/EGFR Inhibitor BGB-283 BRAFV600/PI3K Inhibitor ASN003 Vemurafenib Dabrafenib Encorafenib Raf/MEK Serine/Threonine Kinase Inhibitor RO5126766

@mdolanme

ukemi commented 6 years ago

@sepatterson