Terms requested by Carolynn Jones

[marijane]

Carolynn has been uploading modules and attempting to tag them with ontology terms. She has identified some that may be missing.

For the course Device 101:

• [x] device development
• [x] 510k
• [x] pre-market approval (PMA)
• [x] device labeling
• [x] device classification

For the course Introduction to Personalized Therapeutics and Pharmacogenics:

• [x] genetics
• [x] genomics
• [x] pharmacogenomics
• [x] disease Risk
• [x] personalized medicine
• [x] personalized therapeutics
• [x] biomarkers
• [x] gene therapy
• [x] drug labeling
• [x] epigenetics
• [x] theranostic
• [x] companion diagnostics

Some of these feel more like keywords than terms to put into the domain hierarchy. Consider adding a free-text keyword property if that turns out to be the case.

[marijane]

(Notes to myself.)

Concept candidates:

• http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18741 (device development)
• http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80442 (510k)
• http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70880 (PMA)
• http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112278 (device classification)
• http://purl.bioontology.org/ontology/CSP/0944-4477 (disease risk)
• http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84342 (personalized medicine)
• http://edamontology.org/topic_3360 (biomarkers)
• http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15238 (gene therapy)
• http://purl.bioontology.org/ontology/MESH/D004348 (drug labeling)
• http://edamontology.org/topic_3295 (epigenetics)
• http://purl.bioontology.org/ontology/MESH/D000068936 (theranostic)

Near synonyms:

• http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62976 (device labeling)

No existing term:

• personalized therapeutics
• companion diagnostics

[marijane]

potential property for keywords: http://schema.org/keywords

[marijane]

As I scour the internet for a definition of "Personalized Therapeutics", particularly how it might be distinguished from "Personalized Medicine", I am growing concerned that all of the following terms may be synonymous:

• Personalized Medicine
• Personalized Therapeutics
• Pharmacogenomics
• Theranostics

Per Words Matter: Distinguishing “Personalized Medicine” and “Biologically Personalized Therapeutics”:

“Personalized medicine” is also sometimes called pharmacogenomics (19), theragnostics or theranostics (20), personalized molecular medicine (21), clinical proteomics (21) or individualized targeted therapy (22), stratified medicine (23), and precision medicine (24,25).

Since these terms originated as keywords all used on the same course, it seems possible to me that they were all used to tag a course in the absence of vocabulary control. If this is the case, and they are truly synonymous, they may need to be collapsed into one class with multiple alternative term annotations.

[marijane]

Another synonym list: http://paceomics.org/wp-content/uploads/2016/01/List-of-terminology-for-personalized-medicine-.pdf