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NMRLipids / NMRlipidsIVPEandPG

NMRlipids IV project, PE and PG lipids
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Response of PC headgroup order parameters to PE and PG #10

Closed ohsOllila closed 3 years ago

ohsOllila commented 4 years ago

According to the electrometer concept, the PC headgroup order parameters are constant upon addition of zwitterionic PE, but increase upon addition of anionic PG, because headgroup tilts more parallel to membrane plane with increasing negative charge at the interface. This is somewhat reproduced in simulations (https://github.com/NMRLipids/NMRlipidsIVPEandPG/blob/master/Figs/HGorderparametersPCvsPEPG-eps-converted-to.pdf), but especially the different responses of different alpha carbon hydrogens is surprising.

Maybe we should calculate the P-N vector angles from these simulations and try to figure out why the alpha carbon hydrogen responses are different.

ohsOllila commented 3 years ago

P-N vector angles are now calculated, but this issue remains unclear. However, the focus of the manuscript is now updated and these results are moved to the supplementary information. Therefore, I close this issue.