The SpatialDecon library implements the SpatialDecon algorithm for mixed cell deconvolution in spatial gene expression datasets. (This algorithm also works in bulk expression profiling data.)
A cell profile matrix with an excessively low scale, e.g. with max values of 1e-3, can produce convergence failures. Add an up-front step to rescale cell profile matrices to the same expression level used by safeTME.
patrickjdanaher
commented
3 years ago
A cell profile matrix with an excessively low scale, e.g. with max values of 1e-3, can produce convergence failures. Add an up-front step to rescale cell profile matrices to the same expression level used by safeTME.