Information content (Shannon entropy) of tissue-specific gene expression (per gene/per pathway/over-all) (filter chapter)
PPI networks per tissue type? Same underlying connections (presumably, but different weightings to up/down regulation). For a subset of genes(?) i.e. associated with a pathway. E.g. a pathway with high information content or an interesting gene/protein (predicted by dcGO/FATHMM to be interesting in a structure way, but not expressed in tissue of interest).
Simulate PPI networks for 2 tissue types for that pathway (a relevant one and an irrelevant one, e.g. endocrine gland and skin if hormone related)
Complexity science related ideas: