botocore version problem in pip install

apparently AWS needs newer botocore? perhaps bump version? is that safe?
8539/urllib3-1.25.7-py2.py3-none-any.whl (125kB)
     |████████████████████████████████| 133kB 16.6MB/s
Collecting vine==1.3.0
  Downloading https://files.pythonhosted.org/packages/7f/60/82c03047396126c8331ceb64da1dc52d4f1317209f32e8fe286d0c07365a/vine-1.3.0-py2.py3-none-any.whl
Collecting werkzeug==0.16.0
  Downloading https://files.pythonhosted.org/packages/ce/42/3aeda98f96e85fd26180534d36570e4d18108d62ae36f87694b476b83d6f/Werkzeug-0.16.0-py2.py3-none-any.whl (327kB)
     |████████████████████████████████| 327kB 16.5MB/s
Collecting xmltodict==0.12.0
  Downloading https://files.pythonhosted.org/packages/28/fd/30d5c1d3ac29ce229f6bdc40bbc20b28f716e8b363140c26eff19122d8a5/xmltodict-0.12.0-py2.py3-none-any.whl
Collecting zipp==0.6.0
  Downloading https://files.pythonhosted.org/packages/74/3d/1ee25a26411ba0401b43c6376d2316a71addcc72ef8690b101b4ea56d76a/zipp-0.6.0-py2.py3-none-any.whl
Requirement already satisfied: setuptools in /usr/lib/python3.8/site-packages (from acme==1.0.0->-r requirements.txt (line 7)) (45.2.0)
**ERROR: awscli 1.18.0 has requirement botocore==1.15.0, but you'll have botocore 1.13.46 which is incompatible.
ERROR: awscli 1.18.0 has requirement rsa<=3.5.0,>=3.1.2, but you'll have rsa 4.0 which is incompatible.
ERROR: awscli 1.18.0 has requirement s3transfer<0.4.0,>=0.3.0, but you'll have s3transfer 0.2.1 which is incompatible.**
Installing collected packages: six, pyopenssl, josepy, requests-toolbelt, pytz, pyrfc3339, mock, acme, alembic-autogenerate-enums, sqlalchemy, mako, python-editor, alembic, vine, amqp, aniso8601, arrow, asyncpool, cffi, bcrypt, billiard, blinker, docutils, urllib3, botocore, s3transfer, boto3, kombu, redis, celery, certsrv, future, pyyaml, jsonlines, cloudflare, dnspython, dnspython3, dyn, itsdangerous, jinja2, werkzeug, flask, flask-bcrypt, flask-cors, flask-mail, flask-sqlalchemy, flask-migrate, flask-principal, flask-replicated, flask-restful, flask-script, gunicorn, hvac, idna, more-itertools, zipp, importlib-metadata, inflection, javaobj-py3, python-json-logger, logmatic-python, marshmallow, marshmallow-sqlalchemy, ndg-httpsclient, pynacl, paramiko, pem, psycopg2, pyasn1-modules, pycryptodomex, twofish, pyjks, pyjwt, python-ldap, raven, sqlalchemy-utils, tabulate, xmltodict
  Found existing installation: six 1.14.0
    Uninstalling six-1.14.0:
ERROR: Could not install packages due to an EnvironmentError: [Errno 13] Permission denied: '/usr/lib/python3.8/site-packages/__pycache__/six.cpython-38.pyc'
Consider using the `--user` option or check the permissions.
Netflix / lemur

botocore version problem in pip install #2919
