Neuropathology-Giessen / GIN-RNA-Panel-Details

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Infant-type hemispheric glioma: NTRK family, ALK, ROS, MET #2

Open DanielAmsel opened 2 years ago

DanielAmsel commented 2 years ago

Louis et al 2021:

"Infant-type hemispheric glioma is a novel type of high-grade glioma that occurs in newborns and infants and that has a distinct molecular profile, with fusion genes involving ALK, ROS1, NTRK1/2/3, or MET."

  1. Clarke M, Mackay A, Ismer B, et al. Infant high-grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes. Cancer Discov. 2020;10(7):942–963.
  2. Guerreiro Stucklin AS, Ryall S, Fukuoka K, et al. Alterations in ALK/ ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019;10(1):4343.