For metastasis and genomics data, we use "negative", "positive" and "equivocal" to populate value_as_concept_id:
Positive – concept_id=9191
Negative – concept_id=9189
Equivocal – concept_id=4172976 (rarely)
I don't think there is anything else that require a negative concept.
Community request:
Convention for representing data that indicates an affirmation of the absence of an event or finding.
"Proven not to have happened"
@cgreich I believe has thoughts on this