How to populate drug_exposure.quantity when the drug is a quantified clinical drug with a divisible dose form (prefilled syringe)

[burrowse]

How to populate drug_exposure.quantity when the drug is a quantified clinical drug with divisible dose forms (injections)

CDM or THEMIS convention?

Themis

Table or Field level?

Field

Is this a general convention?

No

Summary of issues

• Quantity is represented several different ways depending on the dose form of a drug.
• For quantified clinical drugs with divisible dose forms it may be unclear how to store quantity.
• The CDM documentation states that: Quantified clinical drugs with divisible dose forms (prefilled syringes), the quantity is the amount of ingredient similar to clinical drugs. Clinical drugs with divisible dose forms (injections) the quantity is the amount of ingredient the patient got. For example, if the injection is 2mg/mL but the patient got 80mL then quantity is reported as 160.
• A recent forum post indicates: if you have Quant Clinical/Branded Drug or a Pack, quantity represents the number of units (syringes, bottles, etc.)

Summary of answer

• To find the dose form of a drug the RELATIONSHIP table can be used where the relationship_id is ‘Has dose form’.
• Quantified clinical drugs with divisible dose forms (prefilled syringes), the quantity is the number of units?

Related links

• CDM Documentation: https://ohdsi.github.io/CommonDataModel/cdm54.html#drug_exposure
• Recent Forum discussion: https://forums.ohdsi.org/t/drugs-with-dose-in-the-name-is-quantity-field-automacally-populated/8318/7
• Outstanding question on the forum on how to calculate quantity for quantified clinical drugs: https://forums.ohdsi.org/t/drug-exposure-quantity/18869/6
• Original Forum Post: https://forums.ohdsi.org/t/proposal-for-conventions-regarding-quantity-and-strength/1015/33 and Wiki Proposal :https://www.ohdsi.org/web/wiki/doku.php?id=documentation:next_cdm:denominator_units related to this topic

[MelaniePhilofsky]

Moving all "quantity" convention issues to Needs More Work column for further review of wording.