In the study design by Muirhead 2002a (PMID: 11879258), erythromycin is only given for 5 days (from Day 2 - 6). In the treatment phase, sildenafil was administered 4 days and 1 h after initiation of erythromycin dosing, i.e. at 97 h. The time values for sildenafil plasma concentrations in the database should thus be shifted by 24 h
In the study design by Muirhead 2002a (PMID: 11879258), erythromycin is only given for 5 days (from Day 2 - 6). In the treatment phase, sildenafil was administered 4 days and 1 h after initiation of erythromycin dosing, i.e. at 97 h. The time values for sildenafil plasma concentrations in the database should thus be shifted by 24 h