I have some difficulties understanding where the Ki of fluvoxamine for CYP3A4 comes from. In the PK-Sim file (and this publication here) the following sources are given for this value:
Yao et al. report a fu in liver microsomes of, on average, 0.33 but no Ki for CYP3A4.
Olesen et al. report a Ki of 24 ± 1.8 µM (SEM).
In PK-Sim there is a Ki,u 1.6 µM which would correspond to a fu,mic of 0.067.
I have some difficulties understanding where the Ki of fluvoxamine for CYP3A4 comes from. In the PK-Sim file (and this publication here) the following sources are given for this value:
Yao et al. report a fu in liver microsomes of, on average, 0.33 but no Ki for CYP3A4. Olesen et al. report a Ki of 24 ± 1.8 µM (SEM). In PK-Sim there is a Ki,u 1.6 µM which would correspond to a fu,mic of 0.067.