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Open-Systems-Pharmacology / Fluvoxamine-Voriconazole-Bupropion-DDI

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CYP2C19 expression profile #1

Open PavelBal opened 2 years ago

PavelBal commented 2 years ago

In this project, the expression of CYP2C19 has adjusted values in small intestinal tissues. These values differ from that used in the CYP2C19 qualification https://github.com/Open-Systems-Pharmacology/Qualification-DDI-CYP2C19

Could you please justify this change? Do you think that "your" expression is the correct one and the models from the qualification network should be adjusted?

PavelBal commented 2 years ago

I apoligize - the CYP2C19 expression used in this model is the default from PK-Sim database. The qualified DDI scenario uses an altered expression.