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How does Pk-Sim adjust administered dose to account for serum protein binding? #117

Closed hualiwu2017 closed 6 years ago

hualiwu2017 commented 6 years ago

If you have 30% bound, will the administered dose be used as input as 100% or reduced by 30%? I cannot see the differential equations in each organ compartment to help me understand that. Thank you very much for any information!!

Aedginto commented 6 years ago

The dose is 100% and not reduced by fraction unbound, as that would be incorrect. The dose would only be reduced if there was a dissolution function that did not reach 100% dissolved; I can’t think of any other way to have <100%. Take care! A.

hualiwu2017 commented 6 years ago

Hi Andrea,

Thank you so much for your reply! This is very helpful. I got the question from a very experienced PBPK modeler for chemical industry. I guess the dose is not reduced by fraction unbound in PK-Sim and felt more confident after you confirm that.

Again thanks and hope you have a wonderful 2018!

Warm regards,

Huali

On Fri, Dec 29, 2017 at 4:21 PM, Andrea Edginton notifications@github.com wrote:

The dose is 100% and not reduced by fraction unbound, as that would be incorrect. The dose would only be reduced if there was a dissolution function that did not reach 100% dissolved; I can’t think of any other way to have <100%. Take care! A.

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