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CYP3A4 DDI #1661

Closed akkayo47 closed 1 year ago

akkayo47 commented 1 year ago

When modeling CYP3A4-mediated DDI, there is a significant change in Cmax and almost constant AUC after drug combination. What parameters can be adjusted?

Or there is a significant change in AUC but no change in Cmax. What parameters can be adjusted?