Originally posted by **xiangetang** March 5, 2024
My drug was excreted by kidney minorly, and the amount of parent drug collected from urine accounted for 3.3% of administered dose, i.e. fe=3.3%, and I already known the toltal plasma clearance calculated by NCA method, which was 9.7 L/h (bioavailability was colse to 1 as well as the absorption fraction in PBPK model ). Therefore, I get the renal plasema clearace=9.7*3.3%, as I put it in the following picture. However, the drug excreated by urine was about 30% in Pksim simulaiton profile. I don't know why? how was the specfic clearance of kidney used to calculted kidney ecreation fraction?
Discussed in https://github.com/Open-Systems-Pharmacology/Forum/discussions/1721