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Database for rat #429

Closed anafunguetto closed 4 years ago

anafunguetto commented 5 years ago

hey, everyone!

would anyone have a database for rat (with cyp/PgP expession)? I need to simulate IP concentrations...

Tks!

HenrikCordes commented 5 years ago

Dear @anafunguetto,

We are currently working on such a database. However, it will still take a while till we make it publicly available. In the mean time you could enter the data manually. What CYP are you looking for?

Kind regards, Henrik

anafunguetto commented 5 years ago

Hi! thanks for the return.

Good to know you´re making this information possible!

We´re looking for pgP expressions in rat (brain, liver and intestine). We are also looking for rat enzyme activities (CYP3A4 and CYP1A2)

Kind regards,

Em seg., 2 de dez. de 2019 às 14:00, HeCo notifications@github.com escreveu:

Dear @anafunguetto https://github.com/anafunguetto,

We are currently working on such a database. However, it will still take a while till we make it publicly available. In the mean time you could enter the data manually. What CYP are you looking for?

Kind regards, Henrik

— You are receiving this because you were mentioned. Reply to this email directly, view it on GitHub https://github.com/Open-Systems-Pharmacology/Forum/issues/429?email_source=notifications&email_token=AN4ZVDXWWTM23OQKRQHLDLDQWU5MFA5CNFSM4JSVHXQ2YY3PNVWWK3TUL52HS4DFVREXG43VMVBW63LNMVXHJKTDN5WW2ZLOORPWSZGOEFUFHHQ#issuecomment-560485278, or unsubscribe https://github.com/notifications/unsubscribe-auth/AN4ZVDROPRDYDQIPTCAHBVDQWU5MFANCNFSM4JSVHXQQ .

-- Ana Cláudia Funguetto Ribeiro

Farmacêutica Mestranda no Programa de Pós Graduação em Ciências Farmacêuticas - Universidade Federal do Pampa - Unipampa Membro do Laboratório de Farmacologia - LabFar Integrante do Grupo de Pesquisa em Nanobiotecnologia e Nanotoxicologia - GPNanoFar (55) 9 9158 - 4063 (Claro)

HenrikCordes commented 4 years ago

Dear @anafunguetto,

sorry for the late response. The Cyp1a2 should only be present in the liver.

In our data base, the expression pattern of P-gp (Abcb1a) (https://www.ncbi.nlm.nih.gov/gene/170913) in the rat look like: image

For CYP3A4 it is a bit more tricky, since there are several homologs in the rat and sex specific differences in expression: image

Further reading: https://www.tandfonline.com/doi/full/10.1517/17425255.2.6.875

Here you should consider liver and intestinal activity.

Hope this helps!

Kind regards, Henrik

anafunguetto commented 4 years ago

Thanks!!!!

Em seg., 16 de dez. de 2019 às 08:16, HeCo notifications@github.com escreveu:

Dear @anafunguetto https://github.com/anafunguetto,

sorry for the late response. The Cyp1a2 should only be present in the liver.

In our data base, the expression pattern of P-gp (Abcb1a) ( https://www.ncbi.nlm.nih.gov/gene/170913) in the rat look like: [image: image] https://user-images.githubusercontent.com/4817133/70902755-bc9fd600-1ffd-11ea-98c8-dc1f900fa187.png

For CYP3A4 it is a bit more tricky, since there are several homologs in the rat and sex specific differences in expression: [image: image] https://user-images.githubusercontent.com/4817133/70902085-51a1cf80-1ffc-11ea-99b9-f6c5dcb448b4.png

Further reading: https://www.tandfonline.com/doi/full/10.1517/17425255.2.6.875

Here you should consider liver and intestinal activity.

Hope this helps!

Kind regards, Henrik

— You are receiving this because you were mentioned. Reply to this email directly, view it on GitHub https://github.com/Open-Systems-Pharmacology/Forum/issues/429?email_source=notifications&email_token=AN4ZVDVXFFPVXMHT5LFO3KLQY5PRTA5CNFSM4JSVHXQ2YY3PNVWWK3TUL52HS4DFVREXG43VMVBW63LNMVXHJKTDN5WW2ZLOORPWSZGOEG6MAQA#issuecomment-566018112, or unsubscribe https://github.com/notifications/unsubscribe-auth/AN4ZVDTKTHYV55JTREXU6RTQY5PRTANCNFSM4JSVHXQQ .

-- Ana Cláudia Funguetto Ribeiro

Farmacêutica Mestranda no Programa de Pós Graduação em Ciências Farmacêuticas - Universidade Federal do Pampa - Unipampa Membro do Laboratório de Farmacologia - LabFar Integrante do Grupo de Pesquisa em Nanobiotecnologia e Nanotoxicologia - GPNanoFar (55) 9 9158 - 4063 (Claro)