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Dabigatran Reversal PBPK Model #464

Closed LMFuhr closed 3 years ago

LMFuhr commented 4 years ago

Dear OSP-community,

We have recently been working on a mechanistic PBPK/PD model to study dabigatran reversal, which includes the reversal of dabigatran by hemodialysis and its antidote idarucizumab.

Therefore, a PBPK model of idarucizumab has been carefully developed and evaluated. The model was then coupled with a recently published PBPK model of dabigatran to predict the interaction of both compounds. The dabigatran model was furthermore extended by a dialyzer compartment and a hemodialysis clearance as well as by a simple PD model.

Related publications: Fuhr LM, Hanke N, Meibohm B, Lehr T Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis Clinical Pharmacokinetics 2020

All models can be found here.

Best regards, Laura

tobiasK2001 commented 4 years ago

Congratulation! Very nice work!