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The solubility for dissolved formulation #474

Closed jzq90 closed 4 years ago

jzq90 commented 4 years ago

I have a compound with poor solubility but dissolved in 5% DMSO which used in the in vivo animal PK study. However, when I build the model for this drug in animals, I found the solubility has a huge impact on bioavailability. In the simulation, I input the formulation as ‘dissolved’ in the software, but apparently it participated in the GIT in the simulation but not in the real world. I think the difference is the DMSO used in the real world. How could I fix this in the model?

prvmalik commented 4 years ago

Hi

Enabling 'supersaturation' in the advanced features should fix this.

Or manually increase the solubility limit in the compound building block.

Paul