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Bootstrapping #478

Closed thPrabhath closed 4 years ago

thPrabhath commented 4 years ago

Is there a way in PK-Sim to resample the and evaluate the parameters by bootstraping. If any please guide me through the process.

msevestre commented 4 years ago

Nothing like that in PKSim. You can do it in Matlab or R. I would suggest you give our new r toolbox a try. It's still in beta but it should be fairly easy to implement this type of scenarios

thPrabhath commented 4 years ago

Thank you for the info. Could you please guide me through that process by which it can be performed in R.

pchelle commented 4 years ago

Using the new R toolbox, you can obtain a data.frame with the PK parameters by individual in a few steps by following the example tests/dev/script-pk-analyses.R Then, you can directly perform the bootstrap analysis using the random sampling with replacement of the R function sample(x, length, replace=TRUE). The process is to create a loop with bootstrap runs on which you use the function sample(), then get the corresponding parameters from the data.frame to which you can aggregate any statistic function.

jzq90 commented 4 years ago

Are there some packages in R for PK-sim?

PavelBal commented 4 years ago

Are there some packages in R for PK-sim?

https://github.com/Open-Systems-Pharmacology/OSPSuite-R