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Kp Sclar value #596

Closed humblewarrior closed 4 years ago

humblewarrior commented 4 years ago

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Hi!

So, after creating simulation for my drug, I looked Kp values for various organs. If you notice in upper right corner there is a scale option, but it looks like its not functioning. No matter what value I change my scale to (e.g. from 1 to 2), it doesn't change corresponding Kp values for organs. Changing scale doesn't change anything. I am wondering what I am missing or what is the purpose of that scale function if its not doing anything?

prvmalik commented 4 years ago

After changing the value in the scale box, you have to press the "Scale" button.

I don't recommend overwriting these, however.

humblewarrior commented 4 years ago

That was so stupid me. Thank you @prvmalik. Why don't you recommend overwriting these, any particular reason?

prvmalik commented 4 years ago

The Kp scalar values are calculated based on organ composition and the physchem properties of the molecule, depending on the calculation method (e.g. Rodgers and Rowland, PK-Sim Standard, Schmitt). It is better to scale them by adjusting the logP value so that the integrity of the calculation methods and organ composition metrics are conserved. Then it is still possible to scale to other populations with other organ compositions (e.g. in the case of pediatrics or geriatrics, obesity and so on).