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How to set up Parent-Metabolite Model #605

Closed humblewarrior closed 4 years ago

humblewarrior commented 4 years ago

Hi!

Is there any tutorial on how to set up parent-metabolote model in PK-Sim. I am getting parent compound tissue concentrations in various organs but I am not sure how to get metabolite concentrations in those same organs even though I have included metabolite information in the building block.

Thank you!

Regards, Sumeet

msevestre commented 4 years ago

@humblewarrior

I have included metabolite information in the building block.

What do you mean by this?

When you want to get metabolite concentrations, the metabolite needs to be a full-blown compound that you will add in the simulation. The linking between the Compound and its metabolite is done at the simulation level

Also please check the documentation. https://docs.open-systems-pharmacology.org/working-with-pk-sim/pk-sim-documentation/pk-sim-simulations#how-to-set-up-a-parent-metabolite-simulation