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Changes of renal clearance rate in elderly  #615

Closed Wenjing1018 closed 3 years ago

Wenjing1018 commented 4 years ago

hello, erveryone: I have a question when I used pk-sim to simulate healthy elderly. healthy people's GFR was 120ml/min, and in "ADME" section , we all know , GFR decreases with age in the elderly, so what happens to the kidney clearance rate when I simulate the elderly?There was any specific relationship between  GFR and renal clearance rates when age changed?With age-related declines in GFR, there's any proportional decline in renal clearance?Or there is any age-related data on kidney clearance rates?

prvmalik commented 4 years ago

Age-related changes in GFR are accounted for by default in PK-Sim according to the work by Jan Schlender and team doi: 10.1007/s40262-016-0422-3

Wenjing1018 commented 4 years ago

@prvmalik ， Your reply is very helpful for me,I wonder kidney plasma clearance rate how to change under the premise of age-related changes in GFR accounted for by default in PK-Sim？ Yours, Sincerely!