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Discussion forum for the Open Systems Pharmacology Project
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New to PBPK modeling #619

Closed pburkat closed 3 years ago

pburkat commented 4 years ago

Good morning, I am new to PBPK modeling, but have extensive experience with pharmacodynamic kinetic modeling. Are there any resources available that help in decision making for parameter modification to improve model fits to data?

Christoph27 commented 4 years ago

Maybe the following tutorial is helpful: doi:10.1002/psp4.12134 Besides describing a typical overall strategy to build a PBPK model, also typically adjusted parameters are mentioned.

pburkat commented 3 years ago

How does one simulate drug concentration in compartments aside from peripheral venous blood and create a plot?

Yuri05 commented 3 years ago

For individual simulations: s. Running a simulation in an individual‌ and Analyzing results for a simulation in an individual‌ For population simulations: s. Running a population simulation‌ and Analyzing a population simulation‌

pburkat commented 3 years ago

How does one increase simulation resolution in PKSim?

Yuri05 commented 3 years ago

You can change the resolution here: grafik

pburkat commented 3 years ago

Where can I find information on how PKSIM handles compound transport into brain and all of its compartments?

pburkat commented 3 years ago

Are the differential equations in PK Sim permeability limited? Of which form?

pburkat commented 3 years ago

Please disregard my last 2 questions.

StephanSchaller commented 3 years ago

@pburkat , please open a new issue for each new question, otherwise your questions might be missed.

For the "permeability limited" question, please see https://github.com/Open-Systems-Pharmacology/Forum/issues/700