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Extracellular Membrane, Intracellular, Interstitial - What Does this mean for the lumen? #716

Closed stwiebe closed 3 years ago

stwiebe commented 3 years ago

Dear OSP community,

I am relatively new to PBPK and am currently trying to implement a simple method to mimic lysosomal trapping in a model I'm working on, using the methods found in this post: #346

When adding an unspecified protein, I have to choose if it is localized interstitially, on the extracellular membrane, or intracellularly: image

If I'm adding the protein in the lumen, I wonder how the different choices affect the calculations/what the different choices (specifically interstitial and intracellular) would mean, given that the lumen is the space inside?

Any help anyone can give to help me better understand this (and which option I should then choose) is very much appreciated - thanks in advance!

Sabrina

StephanSchaller commented 3 years ago

Dear Sabrina,

this setting only affects the entries fur "tissues". Lumen is not part of the tissue and not affected by this choice.

stwiebe commented 3 years ago

Thank you very much for the quick response, Stephan! I’m glad to see it doesn’t make a difference for the lumen, as we were a little confused as to how that would work…