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Meropenem #86

Closed moulirc closed 7 years ago

moulirc commented 7 years ago

I am trying to build a PBPK model for meropenem. 70% of the drug is excreted unchanged in urine. I would like to know if I am missing anything? Thanks in advance. kind regards Mouli Meropenam.pdf

PavelBal commented 7 years ago

You have to implement excretion into urine - at least include GFR. If GFR is not sufficient, add active tubular secretion (which could be P-gp mediated).

moulirc commented 7 years ago

Thanks for your comments.

moulirc commented 7 years ago

I am trying to build a PBPK model for Meropenem. I was following the example (Ciprofloxacin) to develop this model.

Blood plasma partition - 0.55, Additional systemic clearance 3.6 l/h, Volume at steady state 0.29.

I have attached the project file - would appreciate if you could guide me on this.

kind regards mouli

https://1drv.ms/f/s!AhXr_1fEjP6e7Ua7c9o1RB5zaibj