OSP Portable

[jgonlop3]

I want to know if there is someone working on portable version of OSP. I think it´s an important topic to think about due the restriction of install procedures in many devices. Thanks

[msevestre]

@jgonlop3 : I am not aware of anyone working on a portable version of OSP. Off the top of my head, here is where admin rights are required during setup:

1. .NET framework install
2. C++ runtime install
3. Registry entries creation (specifies where PK-Sim and MoBi are installed on the machine so that tools can communicate with each other)
4. Windows Startup menus etc.. (that can probably be installed per user but I am not sure if this would work with some very strict restrictions policies)

I think 1. and 2. cannot be overcome. You need admin rights for these. That being said, these packages are standard microsoft packages and they are in general available on devices.

3. would require changes in the way an app (e.g. PK-Sim) discovers where another app (e.g. MoBi) is installed. An idea would be to ask the user to specify the path of MoBi install if not found in the registry.

4. would require changes in all packages and setup.

Last but not least, a portable setup would have to be created that would assume that .NET Framework and C++ runtime are already installed on the machine

[jgonlop3]

I am afraid this is very difficult to do... I know these limitations and I think it can´t be possible. Anyway, thanks a lot for the answer!

[msevestre]

@jgonlop3 In my opinion, 3. and 4. can be done fairly easily. Some distribution of Windows already come with .NET framework installed so 1. could be solve out of the box depending on which windows OS version is used. I am not sure about 2.

[jgonlop3]

In this case, Why don't try to made a portable version? I know it doesn't work in some scenarios because 1. and 2. but in many cases it can run. Make OPS portable will be a great advance for many people like me.

2017-05-16 19:37 GMT+02:00 Michael Sevestre notifications@github.com:

@jgonlop3 https://github.com/jgonlop3 In my opinion, 3. and 4. can be done fairly easily. Some distribution of Windows already come with .NET framework installed so

1. could be solve out of the box depending on which windows OS version is used. I am not sure about 2.

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[msevestre]

@jgonlop3 agreed. That would be a good contribution for anyone willing to help

[jgonlop3]

Hi again Michael, another important topic is to make a catalogue of substances/drugs with all the basic properties pre-configured. Does this already exists? I try to configure vancomycin for test PK-Sim predictions with real human data and I have a lot of doubts about configure renal and biliary elimination. I have renal elimination rates in mL/min (Cockroft-Gault) but I need mL/min/100 g organ in PK-Sim. How can I do it? Thanks in advance

2017-05-16 20:59 GMT+02:00 Michael Sevestre notifications@github.com:

@jgonlop3 https://github.com/jgonlop3 agreed. That would be a good contribution for anyone willing to help

— You are receiving this because you were mentioned. Reply to this email directly, view it on GitHub https://github.com/Open-Systems-Pharmacology/Forum/issues/9#issuecomment-301881414, or mute the thread https://github.com/notifications/unsubscribe-auth/AEQnqXj6WN5WcT0v2-hBgbqeFSCflU01ks5r6fIggaJpZM4NcWMJ .

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[TheiBa]

@jgonlop3: please open new issues for new topics, otherwise we get a mess (on the long-run).

Content-wise: good point, we discussed an interface to drug-bank in the past, but have not prioritized it high enough in the past, as putting the basic information in, is usually only the smaller part of the overall work.

Regarding vancomycin, I recommend contacting our colleagues in Münster, not sure how active they are already here, see their work: https://www.ncbi.nlm.nih.gov/pubmed/28039606

[hempege]

Dear @jgonlop3, feel free to contact us regarding Vancomycin PbPk.. With best regards Georg

[jgonlop3]

Sorry @TheiBa, you have reason about get a mess if I mix new issues. This issue is for PORTABLE OSP. I will open a new issue for the molecules catalogue.

[jgonlop3]

Hi @hempege, please, I open a new issue to talk about vancomycin PBPK. I will continue inside on this new issue.

[msevestre]

see https://github.com/Open-Systems-Pharmacology/Forum/issues/10

[msevestre]

@jgonlop3 FYI: Portable version of PK-Sim and MoBi (e.g. archive folder to unzip somewhere) has been accepted and will be implemented for the upcoming release.

[jgonlop3]

@msevestre Great news! Thanks